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Okubadejo, Njideka U.; Okunoye, Olaitan; Ojo, Oluwadamilola O.; Arabambi, Babawale; Akinyemi, Rufus O.; Osaigbovo, Godwin O.; Abubakar, Sani A.; Iwuozo, Emmanuel U.; Wahab, Kolawole W.; Agabi, Osigwe P.; Agulanna, Uchechi; Imarhiagbe, Frank A.; Abiodun, Oladunni V.; Achoru, Charles O.; Adebowale, Akintunde A.; Adeniji, Olaleye; Akpekpe, John E.; Ali, Mohammed W.; Ani-Osheku, Ifeyinwa; Arigbodi, Ohwotemu; Balarabe, Salisu A.; Bello, Abiodun H.; Ekenze, Oluchi S.; Erameh, Cyril O.; [...]

APOE E4 is associated with impaired self-declared cognition but not disease risk or age of onset in Nigerians with Parkinson’s disease

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  • Media type: E-Article
  • Title: APOE E4 is associated with impaired self-declared cognition but not disease risk or age of onset in Nigerians with Parkinson’s disease
  • Contributor: Okubadejo, Njideka U.; Okunoye, Olaitan; Ojo, Oluwadamilola O.; Arabambi, Babawale; Akinyemi, Rufus O.; Osaigbovo, Godwin O.; Abubakar, Sani A.; Iwuozo, Emmanuel U.; Wahab, Kolawole W.; Agabi, Osigwe P.; Agulanna, Uchechi; Imarhiagbe, Frank A.; Abiodun, Oladunni V.; Achoru, Charles O.; Adebowale, Akintunde A.; Adeniji, Olaleye; Akpekpe, John E.; Ali, Mohammed W.; Ani-Osheku, Ifeyinwa; Arigbodi, Ohwotemu; Balarabe, Salisu A.; Bello, Abiodun H.; Ekenze, Oluchi S.; Erameh, Cyril O.; [...]
  • imprint: Springer Science and Business Media LLC, 2022
  • Published in: npj Parkinson's Disease
  • Language: English
  • DOI: 10.1038/s41531-022-00411-x
  • ISSN: 2373-8057
  • Keywords: Cellular and Molecular Neuroscience ; Neurology (clinical) ; Neurology
  • Origination:
  • Footnote:
  • Description: <jats:title>Abstract</jats:title><jats:p>The relationship between <jats:italic>APOE</jats:italic> polymorphisms and Parkinson’s disease (PD) in black Africans has not been previously investigated. We evaluated the association between <jats:italic>APOE</jats:italic> polymorphic variability and self-declared cognition in 1100 Nigerians with PD and 1097 age-matched healthy controls. Cognition in PD was assessed using the single item cognition question (item 1.1) of the MDS-UPDRS. <jats:italic>APOE</jats:italic> genotype and allele frequencies did not differ between PD and controls (<jats:italic>p</jats:italic> &gt; 0.05). No allelic or genotypic association was observed between <jats:italic>APOE</jats:italic> and age at onset of PD. In PD, <jats:italic>APOE ε</jats:italic>4/<jats:italic>ε</jats:italic>4 conferred a two-fold risk of cognitive impairment compared to one or no <jats:italic>ε</jats:italic>4 (HR: 2.09 (95% CI: 1.13–3.89; <jats:italic>p</jats:italic> = 0.02)), while <jats:italic>APOE ε</jats:italic>2 was associated with modest protection against cognitive impairment (HR: 0.41 (95% CI 0.19–0.99, <jats:italic>p</jats:italic> = 0.02)). Of 773 PD with motor phenotype and <jats:italic>APOE</jats:italic> characterized, tremor-dominant (TD) phenotype predominated significantly in ε2 carriers (87/135, 64.4%) compared to 22.2% in persons with postural instability/gait difficulty (PIGD) (30/135) and 13.3% in indeterminate (ID) (18/135, 13.3%) (<jats:italic>p</jats:italic> = 0.037). Although the frequency of the TD phenotype was highest in homozygous <jats:italic>ε</jats:italic>2 carriers (85.7%), the distribution of motor phenotypes across the six genotypes did not differ significantly (<jats:italic>p</jats:italic> = 0.18). Altogether, our findings support previous studies in other ethnicities, implying a role for <jats:italic>APOE ε</jats:italic>4 and <jats:italic>ε</jats:italic>2 as risk and protective factors, respectively, for cognitive impairment in PD.</jats:p>
  • Access State: Open Access