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Mariz, Filipe Colaço; Bender, Noemi; Anantharaman, Devasena; Basu, Partha; Bhatla, Neerja; Pillai, Madhavan Radhakrisna; Prabhu, Priya R.; Sankaranarayanan, Rengaswamy; Eriksson, Tiina; Pawlita, Michael; Prager, Kristina; Sehr, Peter; Waterboer, Tim; Müller, Martin; Lehtinen, Matti

Peak neutralizing and cross-neutralizing antibody levels to human papillomavirus types 6/16/18/31/33/45/52/58 induced by bivalent and quadrivalent HPV vaccines

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  • Media type: E-Article
  • Title: Peak neutralizing and cross-neutralizing antibody levels to human papillomavirus types 6/16/18/31/33/45/52/58 induced by bivalent and quadrivalent HPV vaccines
  • Contributor: Mariz, Filipe Colaço; Bender, Noemi; Anantharaman, Devasena; Basu, Partha; Bhatla, Neerja; Pillai, Madhavan Radhakrisna; Prabhu, Priya R.; Sankaranarayanan, Rengaswamy; Eriksson, Tiina; Pawlita, Michael; Prager, Kristina; Sehr, Peter; Waterboer, Tim; Müller, Martin; Lehtinen, Matti
  • imprint: Springer Science and Business Media LLC, 2020
  • Published in: npj Vaccines
  • Language: English
  • DOI: 10.1038/s41541-020-0165-x
  • ISSN: 2059-0105
  • Origination:
  • Footnote:
  • Description: <jats:title>Abstract</jats:title><jats:p>We performed an independent comparison of neutralizing and cross-neutralizing antibody (ab) levels seven months after initiation of three-dose, six-month vaccination schedules with the bivalent and quadrivalent human papillomavirus (HPV) vaccines in adolescent Finnish and Indian females, respectively. We used a semi-automated Pseudovirion-Based Neutralization Assay and observed significantly higher HPV16/18 peak ab-levels in bivalent as compared to quadrivalent vaccine recipients. Bivalent vaccine induced cross-neutralizing HPV31/33/45/52/58 antibodies significantly more frequently and to higher levels than the quadrivalent vaccine. The correlation of bivalent vaccine-induced HPV45 ab-levels with HPV16/18 ab-levels was stronger than that of corresponding quadrivalent vaccine-induced ab-levels, suggesting a qualitatively different cross-reactive response. Our findings on the comparison of the immunogenicity of two HPV vaccine tested in two different populations indicate that further head-to-head studies are warranted.</jats:p>
  • Access State: Open Access