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Seaton, Kelly E.; Deal, Aaron; Han, Xue; Li, Shuying S.; Clayton, Ashley; Heptinstall, Jack; Duerr, Ann; Allen, Mary A.; Shen, Xiaoying; Sawant, Sheetal; Yates, Nicole L.; Spearman, Paul; Churchyard, Gavin; Goepfert, Paul A.; Maenza, Janine; Gray, Glenda; Pantaleo, Giuseppe; Polakowski, Laura; Robinson, Harriet L.; Grant, Shannon; Randhawa, April K.; Huang, Ying; Morgan, Cecilia; Grunenberg, Nicole; [...]

Meta-analysis of HIV-1 vaccine elicited mucosal antibodies in humans

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  • Media type: E-Article
  • Title: Meta-analysis of HIV-1 vaccine elicited mucosal antibodies in humans
  • Contributor: Seaton, Kelly E.; Deal, Aaron; Han, Xue; Li, Shuying S.; Clayton, Ashley; Heptinstall, Jack; Duerr, Ann; Allen, Mary A.; Shen, Xiaoying; Sawant, Sheetal; Yates, Nicole L.; Spearman, Paul; Churchyard, Gavin; Goepfert, Paul A.; Maenza, Janine; Gray, Glenda; Pantaleo, Giuseppe; Polakowski, Laura; Robinson, Harriet L.; Grant, Shannon; Randhawa, April K.; Huang, Ying; Morgan, Cecilia; Grunenberg, Nicole; [...]
  • Published: Springer Science and Business Media LLC, 2021
  • Published in: npj Vaccines, 6 (2021) 1
  • Language: English
  • DOI: 10.1038/s41541-021-00305-8
  • ISSN: 2059-0105
  • Keywords: Pharmacology (medical) ; Infectious Diseases ; Pharmacology ; Immunology
  • Origination:
  • Footnote:
  • Description: AbstractWe studied mucosal immune responses in six HIV-1 vaccine trials investigating different envelope (Env)-containing immunogens. Regimens were classified into four categories: DNA/vector, DNA/vector plus protein, protein alone, and vector alone. We measured HIV-1-specific IgG and IgA in secretions from cervical (n = 111) and rectal swabs (n = 154), saliva (n = 141), and seminal plasma (n = 124) and compared to corresponding blood levels. Protein-containing regimens had up to 100% response rates and the highest Env-specific IgG response rates. DNA/vector groups elicited mucosal Env-specific IgG response rates of up to 67% that varied across specimen types. Little to no mucosal IgA responses were observed. Overall, gp41- and gp140-specific antibodies dominated gp120 mucosal responses. In one trial, prior vaccination with a protein-containing immunogen maintained durability of cervical and rectal IgG for up to 17 years. Mucosal IgG responses were boosted after revaccination. These findings highlight a role for protein immunization in eliciting HIV-1-specific mucosal antibodies and the ability of HIV-1 vaccines to elicit durable HIV-1-specific mucosal IgG.
  • Access State: Open Access