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Yakneen, Sergei;
Waszak, Sebastian M.;
Aminou, Brice;
Bartolome, Javier;
Boroevich, Keith A.;
Boyce, Rich;
Brooks, Angela N.;
Buchanan, Alex;
Buchhalter, Ivo;
Butler, Adam P.;
Byrne, Niall J.;
Cafferkey, Andy;
Campbell, Peter J.;
Chen, Zhaohong;
Cho, Sunghoon;
Choi, Wan;
Clapham, Peter;
Davis-Dusenbery, Brandi N.;
De La Vega, Francisco M.;
Demeulemeester, Jonas;
Dow, Michelle T.;
Dursi, Lewis Jonathan;
Eils, Juergen;
Eils, Roland;
[...]
Butler enables rapid cloud-based analysis of thousands of human genomes
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- Media type: E-Article
- Title: Butler enables rapid cloud-based analysis of thousands of human genomes
- Contributor: Yakneen, Sergei; Waszak, Sebastian M.; Aminou, Brice; Bartolome, Javier; Boroevich, Keith A.; Boyce, Rich; Brooks, Angela N.; Buchanan, Alex; Buchhalter, Ivo; Butler, Adam P.; Byrne, Niall J.; Cafferkey, Andy; Campbell, Peter J.; Chen, Zhaohong; Cho, Sunghoon; Choi, Wan; Clapham, Peter; Davis-Dusenbery, Brandi N.; De La Vega, Francisco M.; Demeulemeester, Jonas; Dow, Michelle T.; Dursi, Lewis Jonathan; Eils, Juergen; Eils, Roland; [...]
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Published:
Springer Science and Business Media LLC, 2020
- Published in: Nature Biotechnology, 38 (2020) 3, Seite 288-292
- Language: English
- DOI: 10.1038/s41587-019-0360-3
- ISSN: 1546-1696; 1087-0156
- Origination:
- Footnote:
- Description: AbstractWe present Butler, a computational tool that facilitates large-scale genomic analyses on public and academic clouds. Butler includes innovative anomaly detection and self-healing functions that improve the efficiency of data processing and analysis by 43% compared with current approaches. Butler enabled processing of a 725-terabyte cancer genome dataset from the Pan-Cancer Analysis of Whole Genomes (PCAWG) project in a time-efficient and uniform manner.