> Details

Thompson, Ryan C.; Simons, Nicole W.; Wilkins, Lillian; Cheng, Esther; Del Valle, Diane Marie; Hoffman, Gabriel E.; Cervia, Carlo; Fennessy, Brian; Mouskas, Konstantinos; Francoeur, Nancy J.; Johnson, Jessica S.; Lepow, Lauren; Le Berichel, Jessica; Chang, Christie; Beckmann, Aviva G.; Wang, Ying-chih; Nie, Kai; Zaki, Nicholas; Tuballes, Kevin; Barcessat, Vanessa; Cedillo, Mario A.; Yuan, Dan; Huckins, Laura; Roussos, Panos; [...]

Molecular states during acute COVID-19 reveal distinct etiologies of long-term sequelae

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  • Media type: E-Article
  • Title: Molecular states during acute COVID-19 reveal distinct etiologies of long-term sequelae
  • Contributor: Thompson, Ryan C.; Simons, Nicole W.; Wilkins, Lillian; Cheng, Esther; Del Valle, Diane Marie; Hoffman, Gabriel E.; Cervia, Carlo; Fennessy, Brian; Mouskas, Konstantinos; Francoeur, Nancy J.; Johnson, Jessica S.; Lepow, Lauren; Le Berichel, Jessica; Chang, Christie; Beckmann, Aviva G.; Wang, Ying-chih; Nie, Kai; Zaki, Nicholas; Tuballes, Kevin; Barcessat, Vanessa; Cedillo, Mario A.; Yuan, Dan; Huckins, Laura; Roussos, Panos; [...]
  • imprint: Springer Science and Business Media LLC, 2023
  • Published in: Nature Medicine
  • Language: English
  • DOI: 10.1038/s41591-022-02107-4
  • ISSN: 1546-170X; 1078-8956
  • Keywords: General Biochemistry, Genetics and Molecular Biology ; General Medicine
  • Origination:
  • Footnote:
  • Description: <jats:title>Abstract</jats:title><jats:p>Post-acute sequelae of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection are debilitating, clinically heterogeneous and of unknown molecular etiology. A transcriptome-wide investigation was performed in 165 acutely infected hospitalized individuals who were followed clinically into the post-acute period. Distinct gene expression signatures of post-acute sequelae were already present in whole blood during acute infection, with innate and adaptive immune cells implicated in different symptoms. Two clusters of sequelae exhibited divergent plasma-cell-associated gene expression patterns. In one cluster, sequelae associated with higher expression of immunoglobulin-related genes in an anti-spike antibody titer-dependent manner. In the other, sequelae associated independently of these titers with lower expression of immunoglobulin-related genes, indicating lower non-specific antibody production in individuals with these sequelae. This relationship between lower total immunoglobulins and sequelae was validated in an external cohort. Altogether, multiple etiologies of post-acute sequelae were already detectable during SARS-CoV-2 infection, directly linking these sequelae with the acute host response to the virus and providing early insights into their development.</jats:p>