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Maddock, Jane; Zhou, Ang; Cavadino, Alana; Kuźma, Elżbieta; Bao, Yanchun; Smart, Melissa C.; Saum, Kai-Uwe; Schöttker, Ben; Engmann, Jorgen; Kjærgaard, Marie; Karhunen, Ville; Zhan, Yiqiang; Lehtimäki, Terho; Rovio, Suvi P.; Byberg, Liisa; Lahti, Jari; Marques-Vidal, Pedro; Sen, Abhijit; Perna, Laura; Schirmer, Henrik; Singh-Manoux, Archana; Auvinen, Juha; Hutri-Kähönen, Nina; Kähönen, Mika; [...]

Vitamin D and cognitive function: A Mendelian randomisation study

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  • Media type: E-Article
  • Title: Vitamin D and cognitive function: A Mendelian randomisation study
  • Contributor: Maddock, Jane; Zhou, Ang; Cavadino, Alana; Kuźma, Elżbieta; Bao, Yanchun; Smart, Melissa C.; Saum, Kai-Uwe; Schöttker, Ben; Engmann, Jorgen; Kjærgaard, Marie; Karhunen, Ville; Zhan, Yiqiang; Lehtimäki, Terho; Rovio, Suvi P.; Byberg, Liisa; Lahti, Jari; Marques-Vidal, Pedro; Sen, Abhijit; Perna, Laura; Schirmer, Henrik; Singh-Manoux, Archana; Auvinen, Juha; Hutri-Kähönen, Nina; Kähönen, Mika; [...]
  • imprint: Springer Science and Business Media LLC, 2017
  • Published in: Scientific Reports
  • Language: English
  • DOI: 10.1038/s41598-017-13189-3
  • ISSN: 2045-2322
  • Keywords: Multidisciplinary
  • Origination:
  • Footnote:
  • Description: <jats:title>Abstract</jats:title><jats:p>The causal nature of the association between hypovitaminosis D and poor cognitive function in mid- to later-life is uncertain. Using a Mendelian randomisation(MR) approach, we examined the causal relationship between 25(OH)D and cognitive function. Data came from 172,349 participants from 17 cohorts. <jats:italic>DHCR7</jats:italic>(rs12785878), <jats:italic>CYP2R1</jats:italic> rs12794714) and their combined <jats:italic>synthesis score</jats:italic> were chosen to proxy 25(OH)D. Cognitive tests were standardised into global and memory scores. Analyses were stratified by 25(OH)D tertiles, sex and age. Random effects meta-analyses assessed associations between 25(OH)D and cognitive function. Associations of serum 25(OH)D with global and memory-related cognitive function were non-linear (lower cognitive scores for both low and high 25(OH)D, <jats:italic>p</jats:italic><jats:sub>curvature</jats:sub> ≤ 0.006), with much of the curvature attributed to a single study. <jats:italic>DHCR7</jats:italic>, <jats:italic>CYP2R1</jats:italic>, and the <jats:italic>synthesis score</jats:italic> were associated with small reductions in 25(OH)D per vitamin D-decreasing allele. However, coefficients for associations with global or memory-related cognitive function were non-significant and in opposing directions for <jats:italic>DHCR7</jats:italic> and <jats:italic>CYP2R1</jats:italic>, with no overall association observed for the <jats:italic>synthesis score</jats:italic>. Coefficients for the <jats:italic>synthesis score</jats:italic> and global and memory cognition were similar when stratified by 25(OH)D tertiles, sex and age. We found no evidence for serum 25(OH)D concentration as a causal factor for cognitive performance in mid- to later life.</jats:p>
  • Access State: Open Access