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Ottaviani, Javier I.; Fong, Reedmond; Kimball, Jennifer; Ensunsa, Jodi L.; Gray, Nicola; Vogiatzoglou, Anna; Britten, Abigail; Lucarelli, Debora; Luben, Robert; Grace, Philip B.; Mawson, Deborah H.; Tym, Amy; Wierzbicki, Antonia; Smith, A. David; Wareham, Nicholas J.; Forouhi, Nita G.; Khaw, Kay-Tee; Schroeter, Hagen; Kuhnle, Gunter G. C.

Evaluation of (−)-epicatechin metabolites as recovery biomarker of dietary flavan-3-ol intake

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  • Media type: E-Article
  • Title: Evaluation of (−)-epicatechin metabolites as recovery biomarker of dietary flavan-3-ol intake
  • Contributor: Ottaviani, Javier I.; Fong, Reedmond; Kimball, Jennifer; Ensunsa, Jodi L.; Gray, Nicola; Vogiatzoglou, Anna; Britten, Abigail; Lucarelli, Debora; Luben, Robert; Grace, Philip B.; Mawson, Deborah H.; Tym, Amy; Wierzbicki, Antonia; Smith, A. David; Wareham, Nicholas J.; Forouhi, Nita G.; Khaw, Kay-Tee; Schroeter, Hagen; Kuhnle, Gunter G. C.
  • imprint: Springer Science and Business Media LLC, 2019
  • Published in: Scientific Reports
  • Language: English
  • DOI: 10.1038/s41598-019-49702-z
  • ISSN: 2045-2322
  • Keywords: Multidisciplinary
  • Origination:
  • Footnote:
  • Description: <jats:title>Abstract</jats:title><jats:p>Data from dietary intervention studies suggest that intake of (−)-epicatechin mediates beneficial vascular effects in humans. However, population-based investigations are required to evaluate associations between habitual intake and health and these studies rely on accurate estimates of intake, which nutritional biomarkers can provide. Here, we evaluate a series of structurally related (−)-epicatechin metabolites (SREM), particularly (−)-epicatechin-3′-glucuronide, (−)-epicatechin-3′-sulfate and 3′-O-methyl-(−)-epicatechin-5-sulfate (SREM<jats:sub>B</jats:sub>), as flavan-3-ol and (−)-epicatechin intake. SREM<jats:sub>B</jats:sub> in urine proved to be a specific indicator of (−)-epicatechin intake, showing also a strong correlation with the amount of (−)-epicatechin ingested (R<jats:sup>2</jats:sup>: 0.86 (95% CI 0.8l; 0.92). The median recovery of (−)-epicatechin as SREM<jats:sub>B</jats:sub> in 24 h urine was 10% (IQR 7–13%) and we found SREM<jats:sub>B</jats:sub> in the majority of participants of EPIC Norfolk (83% of 24,341) with a mean concentration of 2.4 ± 3.2 µmol/L. Our results show that SREM<jats:sub>B</jats:sub> are suitable as biomarker of (−)-epicatechin intake. According to evaluation criteria from IARC and the Institute of Medicine, the results obtained support use of SREM<jats:sub>B</jats:sub> as a recovery biomarker to estimate actual intake of (−)-epicatechin.</jats:p>
  • Access State: Open Access