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Herr, Wiebke; Krumkamp, Ralf; Hogan, Benedikt; Dekker, Denise; Gyau, Kennedy; Owusu-Dabo, Ellis; Sarpong, Nimako; Jaeger, Anna; Loag, Wibke; Winter, Doris; Akenten, Charity Wiafe; Eibach, Daniel; Fickenscher, Helmut; Eis-Hübinger, Anna; May, Jürgen; Kreuels, Benno

A cross-sectional study on risk factors for infection with Parvovirus B19 and the association with anaemia in a febrile paediatric population in Ghana

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  • Media type: E-Article
  • Title: A cross-sectional study on risk factors for infection with Parvovirus B19 and the association with anaemia in a febrile paediatric population in Ghana
  • Contributor: Herr, Wiebke; Krumkamp, Ralf; Hogan, Benedikt; Dekker, Denise; Gyau, Kennedy; Owusu-Dabo, Ellis; Sarpong, Nimako; Jaeger, Anna; Loag, Wibke; Winter, Doris; Akenten, Charity Wiafe; Eibach, Daniel; Fickenscher, Helmut; Eis-Hübinger, Anna; May, Jürgen; Kreuels, Benno
  • imprint: Springer Science and Business Media LLC, 2020
  • Published in: Scientific Reports
  • Language: English
  • DOI: 10.1038/s41598-020-72657-5
  • ISSN: 2045-2322
  • Keywords: Multidisciplinary
  • Origination:
  • Footnote:
  • Description: <jats:title>Abstract</jats:title><jats:p><jats:italic>Parvovirus B19</jats:italic> (B19V) occurs globally and can cause severe anaemia. The role of co-infections with <jats:italic>Plasmodium falciparum</jats:italic> (<jats:italic>P. falciparum)</jats:italic> has been controversially discussed. The study aimed to determine prevalence and severity of B19V infection, and the effect of co-infections on the risk for anaemia. Between November 2013 and April 2015 a total of 1186 hospital visits of children with fever admitted to a hospital in Ghana were recorded. Malaria, B19V and additional diagnostics for fever causes were performed. Recent B19V infection was defined as PCR and/or IgM positivity. Risk factors for a B19V infection and for anaemia were analysed. The prevalence of anaemia was compared between children with/without B19V infection, stratified for the presence of malaria. B19V IgM/PCR was positive in 6.4% (n = 76; 40 IgM + , 30 PCR + , 6 IgM + and PCR +). Among the B19V cases 60.5% had a simultaneous <jats:italic>P. falciparum</jats:italic> infection. B19V IgM positivity but not PCR positivity was associated with moderate-severe anaemia (OR = 2.6; 95%-CI: 1.3–5.3; <jats:italic>P</jats:italic> &lt; 0.01 vs. OR = 0.9; 95%-CI: 0.4–1.8; <jats:italic>P</jats:italic> = 0.70). <jats:italic>P. falciparum</jats:italic> and IgM positive B19V infection were independent risk factors for anaemia with no evidence of effect modification. Our data show a significant association between B19V infection, defined as IgM but not PCR positivity, and moderate-severe anaemia. A multiplicative effect of B19V and <jats:italic>P. falciparum</jats:italic> infection was not found.</jats:p>
  • Access State: Open Access