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Masuda, Hiroki; Mori, Masahiro; Hirano, Shigeki; Uzawa, Akiyuki; Uchida, Tomohiko; Muto, Mayumi; Ohtani, Ryohei; Aoki, Reiji; Hirano, Yoshiyuki; Iwatsubo, Takeshi; Asada, Takashi; Arai, Hiroyuki; Sugishita, Morihiro; Matsuda, Hiroshi; Ito, Kengo; Senda, Michio; Ishii, Kenji; Kuwano, Ryozo; Ikeuchi, Takeshi; Sato, Noriko; Sato, Hajime; Shimohama, Shun; Saitoh, Masaki; Yamauchi, Rika; [...]

Higher longitudinal brain white matter atrophy rate in aquaporin-4 IgG-positive NMOSD compared with healthy controls

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  • Media type: E-Article
  • Title: Higher longitudinal brain white matter atrophy rate in aquaporin-4 IgG-positive NMOSD compared with healthy controls
  • Contributor: Masuda, Hiroki; Mori, Masahiro; Hirano, Shigeki; Uzawa, Akiyuki; Uchida, Tomohiko; Muto, Mayumi; Ohtani, Ryohei; Aoki, Reiji; Hirano, Yoshiyuki; Iwatsubo, Takeshi; Asada, Takashi; Arai, Hiroyuki; Sugishita, Morihiro; Matsuda, Hiroshi; Ito, Kengo; Senda, Michio; Ishii, Kenji; Kuwano, Ryozo; Ikeuchi, Takeshi; Sato, Noriko; Sato, Hajime; Shimohama, Shun; Saitoh, Masaki; Yamauchi, Rika; [...]
  • Published: Springer Science and Business Media LLC, 2023
  • Published in: Scientific Reports, 13 (2023) 1
  • Language: English
  • DOI: 10.1038/s41598-023-38893-1
  • ISSN: 2045-2322
  • Origination:
  • Footnote:
  • Description: AbstractWe aimed to compare longitudinal brain atrophy in patients with neuromyelitis optica spectrum disorder (NMOSD) with healthy controls (HCs). The atrophy rate in patients with anti-aquaporin-4 antibody-positive NMOSD (AQP4 + NMOSD) was compared with age-sex-matched HCs recruited from the Japanese Alzheimer’s Disease Neuroimaging Initiative study and another study performed at Chiba University. Twenty-nine patients with AQP4 + NMOSD and 29 HCs were enrolled in the study. The time between magnetic resonance imaging (MRI) scans was longer in the AQP4 + NMOSD group compared with the HCs (median; 3.2 vs. 2.9 years, P = 0.009). The annualized normalized white matter volume (NWV) atrophy rate was higher in the AQP4 + NMOSD group compared with the HCs (median; 0.37 vs. − 0.14, P = 0.018). The maximum spinal cord lesion length negatively correlated with NWV at baseline MRI in patients with AQP4 + NMOSD (Spearman’s rho =  − 0.41, P = 0.027). The annualized NWV atrophy rate negatively correlated with the time between initiation of persistent prednisolone usage and baseline MRI in patients with AQP4 + NMOSD (Spearman’s rho =  − 0.43, P = 0.019). Patients with AQP4 + NMOSD had a greater annualized NWV atrophy rate than HCs. Suppressing disease activity may prevent brain atrophy in patients with AQP4 + NMOSD.
  • Access State: Open Access