> Details

Balloff, Carolin; Bandlow, Carolina; Bernhard, Michael; Brandenburger, Timo; Bludau, Patricia; Elben, Saskia; Feldt, Torsten; Hartmann, Christian J.; Heinen, Elisa; Ingwersen, Jens; Jansen, Corinna; Jensen, Björn-Erik O.; Kindgen-Milles, Detlef; Luedde, Tom; Penner, Iris-Katharina; Slink, Isabel; Stramm, Kim; Telke, Ann-Kathrin; Timm, Jörg; Vetterkind, Lana; Vollmer, Christian; Wolff, Georg; Schnitzler, Alfons; Meuth, Sven G.; [...]

Prevalence and prognostic value of neurological affections in hospitalized patients with moderate to severe COVID-19 based on objective assessments

Reference
management

Bookmarks

Remove from
bookmarks

Share this on Whatsapp

Close

Bookmarks



You can manage bookmarks using lists, please log in to your user account for this.
  • Media type: E-Article
  • Title: Prevalence and prognostic value of neurological affections in hospitalized patients with moderate to severe COVID-19 based on objective assessments
  • Contributor: Balloff, Carolin; Bandlow, Carolina; Bernhard, Michael; Brandenburger, Timo; Bludau, Patricia; Elben, Saskia; Feldt, Torsten; Hartmann, Christian J.; Heinen, Elisa; Ingwersen, Jens; Jansen, Corinna; Jensen, Björn-Erik O.; Kindgen-Milles, Detlef; Luedde, Tom; Penner, Iris-Katharina; Slink, Isabel; Stramm, Kim; Telke, Ann-Kathrin; Timm, Jörg; Vetterkind, Lana; Vollmer, Christian; Wolff, Georg; Schnitzler, Alfons; Meuth, Sven G.; [...]
  • imprint: Springer Science and Business Media LLC, 2023
  • Published in: Scientific Reports
  • Language: English
  • DOI: 10.1038/s41598-023-46124-w
  • ISSN: 2045-2322
  • Keywords: Multidisciplinary
  • Origination:
  • Footnote:
  • Description: <jats:title>Abstract</jats:title><jats:p>Neurological manifestations of coronavirus disease 2019 (COVID-19) have been frequently described. In this prospective study of hospitalized COVID-19 patients without a history of neurological conditions, we aimed to analyze their prevalence and prognostic value based on established, standardized and objective methods. Patients were investigated using a multimodal electrophysiological approach, accompanied by neuropsychological and neurological examinations. Prevalence rates of central (CNS) and peripheral (PNS) nervous system affections were calculated and the relationship between neurological affections and mortality was analyzed using Firth logistic regression models. 184 patients without a history of neurological diseases could be enrolled. High rates of PNS affections were observed (66% of 138 patients receiving electrophysiological PNS examination). CNS affections were less common but still highly prevalent (33% of 139 examined patients). 63% of patients who underwent neuropsychological testing (<jats:italic>n</jats:italic> = 155) presented cognitive impairment. Logistic regression models revealed pathology in somatosensory evoked potentials as an independent risk factor of mortality (Odds Ratio: 6.10 [1.01–65.13], <jats:italic>p</jats:italic> = 0.049). We conclude that hospitalized patients with moderate to severe COVID-19 display high rates of PNS and CNS affection, which can be objectively assessed by electrophysiological examination. Electrophysiological assessment may have a prognostic value and could thus be helpful to identify patients at risk for deterioration.</jats:p>
  • Access State: Open Access