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Goh, Yun Shan; Fong, Siew-Wai; Tay, Matthew Zirui; Rouers, Angeline; Chang, Zi Wei; Chavatte, Jean-Marc; Hor, Pei Xiang; Loh, Chiew Yee; Huang, Yuling; Tan, Yong Jie; Wang, Bei; Ngoh, Eve Zi Xian; Mohd Salleh, Siti Nazihah; Lee, Raphael Tze Chuen; Lim, Georgina; Yu, Jocelyn Jin; Soh, Zheng Kuang; Chin, Yi Qing; Lim, Jonathan Jordon; Ongko, Juwinda; Libau, Eshele Anak; Abdullah, Mohammed Ridzwan Bin; Diong, Shiau Hui; Teo, Jefanie; [...]

Higher Delta variant-specific neutralizing antibodies prevented infection in close contacts vaccinated with ancestral mRNA vaccines during the SARS-CoV-2 Delta wave

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  • Media type: E-Article
  • Title: Higher Delta variant-specific neutralizing antibodies prevented infection in close contacts vaccinated with ancestral mRNA vaccines during the SARS-CoV-2 Delta wave
  • Contributor: Goh, Yun Shan; Fong, Siew-Wai; Tay, Matthew Zirui; Rouers, Angeline; Chang, Zi Wei; Chavatte, Jean-Marc; Hor, Pei Xiang; Loh, Chiew Yee; Huang, Yuling; Tan, Yong Jie; Wang, Bei; Ngoh, Eve Zi Xian; Mohd Salleh, Siti Nazihah; Lee, Raphael Tze Chuen; Lim, Georgina; Yu, Jocelyn Jin; Soh, Zheng Kuang; Chin, Yi Qing; Lim, Jonathan Jordon; Ongko, Juwinda; Libau, Eshele Anak; Abdullah, Mohammed Ridzwan Bin; Diong, Shiau Hui; Teo, Jefanie; [...]
  • imprint: Springer Science and Business Media LLC, 2023
  • Published in: Scientific Reports
  • Language: English
  • DOI: 10.1038/s41598-023-46800-x
  • ISSN: 2045-2322
  • Keywords: Multidisciplinary
  • Origination:
  • Footnote:
  • Description: <jats:title>Abstract</jats:title><jats:p>Identification of the risk factors and the high-risk groups which are most vulnerable is critical in COVID-19 disease management at a population level. Evaluating the efficacy of vaccination against infections is necessary to determine booster vaccination strategies for better protection in high-risk groups. In this study, we recruited 158 mRNA-vaccinated individuals during the Delta wave of SARS-CoV-2 infections in Singapore and examined the antibody profiles of infected individuals. We found that, despite high exposure due to communal living conditions in proximity, 4% of individuals (6/158) had PCR-confirmed infections and 96% (152/158) remained uninfected. Time-course analysis of the antibody profile at the start and the end of quarantine period showed Delta-specific boosting of anti-spike antibody response in 57% of the uninfected individuals (86/152). In the remaining 43% of the uninfected individuals (66/152) with no Delta-specific antibody boost, we found a higher Delta-specific antibody response at the start of quarantine period, which correlated with higher Delta pseudovirus neutralizing capacity. Our findings indicate that a higher basal variant-specific antibody response in the mRNA-vaccinated individuals contributes to better protection against infections by the new emerging SARS-CoV-2 variants.</jats:p>
  • Access State: Open Access