Udden, S. M. Nashir;
Baek, GuemHee;
Pandey, Kamal;
Vidal, Chantal;
Liu, Yulun;
Rahimi, Asal S.;
Kim, D. Nathan;
Nwachukwu, Chika R.;
Mani, Ram S.;
Alluri, Prasanna G.
Towards precision radiation oncology: endocrine therapy response as a biomarker for personalization of breast radiotherapy
You can manage bookmarks using lists, please log in to your user account for this.
Media type:
E-Article
Title:
Towards precision radiation oncology: endocrine therapy response as a biomarker for personalization of breast radiotherapy
Contributor:
Udden, S. M. Nashir;
Baek, GuemHee;
Pandey, Kamal;
Vidal, Chantal;
Liu, Yulun;
Rahimi, Asal S.;
Kim, D. Nathan;
Nwachukwu, Chika R.;
Mani, Ram S.;
Alluri, Prasanna G.
Published:
Springer Science and Business Media LLC, 2023
Description:
AbstractTargeted therapies, such as endocrine therapies (ET), can exert selective pressure on cancer cells and promote adaptations that confer treatment resistance. In this study, we show that ET resistance in breast cancer drives radiation resistance through reprogramming of DNA repair pathways. We also show that pharmacological bromodomain and extraterminal domain inhibition reverses pathological DNA repair reprogramming in ET-resistant breast tumors and overcomes resistance to radiation therapy.