> Details

Prutsch, Nicole; Gurnhofer, Elisabeth; Suske, Tobias; Liang, Huan Chang; Schlederer, Michaela; Roos, Simone; Wu, Lawren C.; Simonitsch-Klupp, Ingrid; Alvarez-Hernandez, Andrea; Kornauth, Christoph; Leone, Dario A.; Svinka, Jasmin; Eferl, Robert; Limberger, Tanja; Aufinger, Astrid; Shirsath, Nitesh; Wolf, Peter; Hielscher, Thomas; Sternberg, Christina; Aberger, Fritz; Schmoellerl, Johannes; Stoiber, Dagmar; Strobl, Birgit; Jäger, Ulrich; [...]

Dependency on the TYK2/STAT1/MCL1 axis in anaplastic large cell lymphoma

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  • Media type: E-Article
  • Title: Dependency on the TYK2/STAT1/MCL1 axis in anaplastic large cell lymphoma
  • Contributor: Prutsch, Nicole; Gurnhofer, Elisabeth; Suske, Tobias; Liang, Huan Chang; Schlederer, Michaela; Roos, Simone; Wu, Lawren C.; Simonitsch-Klupp, Ingrid; Alvarez-Hernandez, Andrea; Kornauth, Christoph; Leone, Dario A.; Svinka, Jasmin; Eferl, Robert; Limberger, Tanja; Aufinger, Astrid; Shirsath, Nitesh; Wolf, Peter; Hielscher, Thomas; Sternberg, Christina; Aberger, Fritz; Schmoellerl, Johannes; Stoiber, Dagmar; Strobl, Birgit; Jäger, Ulrich; [...]
  • imprint: Springer Science and Business Media LLC, 2019
  • Published in: Leukemia
  • Language: English
  • DOI: 10.1038/s41375-018-0239-1
  • ISSN: 0887-6924; 1476-5551
  • Origination:
  • Footnote:
  • Description: <jats:title>Abstract</jats:title><jats:p>TYK2 is a member of the JAK family of tyrosine kinases that is involved in chromosomal translocation-induced fusion proteins found in anaplastic large cell lymphomas (ALCL) that lack rearrangements activating the anaplastic lymphoma kinase (ALK). Here we demonstrate that TYK2 is highly expressed in all cases of human ALCL, and that in a mouse model of NPM-ALK-induced lymphoma, genetic disruption of <jats:italic>Tyk2</jats:italic> delays the onset of tumors and prolongs survival of the mice. Lymphomas in this model lacking <jats:italic>Tyk2</jats:italic> have reduced STAT1 and STAT3 phosphorylation and reduced expression of <jats:italic>Mcl1</jats:italic>, a pro-survival member of the BCL2 family. These findings in mice are mirrored in human ALCL cell lines, in which TYK2 is activated by autocrine production of IL-10 and IL-22 and by interaction with specific receptors expressed by the cells. Activated TYK2 leads to STAT1 and STAT3 phosphorylation, activated expression of MCL1 and aberrant ALCL cell survival. Moreover, TYK2 inhibitors are able to induce apoptosis in ALCL cells, regardless of the presence or absence of an ALK-fusion. Thus, TYK2 is a dependency that is required for ALCL cell survival through activation of MCL1 expression. TYK2 represents an attractive drug target due to its essential enzymatic domain, and TYK2-specific inhibitors show promise as novel targeted inhibitors for ALCL.</jats:p>
  • Access State: Open Access