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Susai, Subash Raj; Healy, Colm; Mongan, David; Heurich, Meike; Byrne, Jonah F.; Cannon, Mary; Cagney, Gerard; Wynne, Kieran; Markulev, Connie; Schäfer, Miriam R.; Berger, Maximus; Mossaheb, Nilufar; Schlögelhofer, Monika; Smesny, Stefan; Hickie, Ian B.; Berger, Gregor E.; Chen, Eric Y. H.; de Haan, Lieuwe; Nieman, Dorien H.; Nordentoft, Merete; Riecher-Rössler, Anita; Verma, Swapna; Street, Rebekah; Thompson, Andrew; [...]

Evidence that complement and coagulation proteins are mediating the clinical response to omega-3 fatty acids: A mass spectrometry-based investigation in subjects at clinical high-risk for psychosis

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  • Media type: E-Article
  • Title: Evidence that complement and coagulation proteins are mediating the clinical response to omega-3 fatty acids: A mass spectrometry-based investigation in subjects at clinical high-risk for psychosis
  • Contributor: Susai, Subash Raj; Healy, Colm; Mongan, David; Heurich, Meike; Byrne, Jonah F.; Cannon, Mary; Cagney, Gerard; Wynne, Kieran; Markulev, Connie; Schäfer, Miriam R.; Berger, Maximus; Mossaheb, Nilufar; Schlögelhofer, Monika; Smesny, Stefan; Hickie, Ian B.; Berger, Gregor E.; Chen, Eric Y. H.; de Haan, Lieuwe; Nieman, Dorien H.; Nordentoft, Merete; Riecher-Rössler, Anita; Verma, Swapna; Street, Rebekah; Thompson, Andrew; [...]
  • Published: Springer Science and Business Media LLC, 2022
  • Published in: Translational Psychiatry, 12 (2022) 1
  • Language: English
  • DOI: 10.1038/s41398-022-02217-0
  • ISSN: 2158-3188
  • Origination:
  • Footnote:
  • Description: <jats:title>Abstract</jats:title><jats:p>Preliminary evidence indicates beneficial effects of omega-3 polyunsaturated fatty acids (PUFAs) in early psychosis. The present study investigates the molecular mechanism of omega-3 PUFA-associated therapeutic effects in clinical high-risk (CHR) participants. Plasma samples of 126 CHR psychosis participants at baseline and 6-months follow-up were included. Plasma protein levels were quantified using mass spectrometry and erythrocyte omega-3 PUFA levels were quantified using gas chromatography. We examined the relationship between change in polyunsaturated PUFAs (between baseline and 6-month follow-up) and follow-up plasma proteins. Using mediation analysis, we investigated whether plasma proteins mediated the relationship between change in omega-3 PUFAs and clinical outcomes. A 6-months change in omega-3 PUFAs was associated with 24 plasma proteins at follow-up. Pathway analysis revealed the complement and coagulation pathway as the main biological pathway to be associated with change in omega-3 PUFAs. Moreover, complement and coagulation pathway proteins significantly mediated the relationship between change in omega-3 PUFAs and clinical outcome at follow-up. The inflammatory protein complement C5 and protein S100A9 negatively mediated the relationship between change in omega-3 PUFAs and positive symptom severity, while C5 positively mediated the relationship between change in omega-3 and functional outcome. The relationship between change in omega-3 PUFAs and cognition was positively mediated through coagulation factor V and complement protein C1QB. Our findings provide evidence for a longitudinal association of omega-3 PUFAs with complement and coagulation protein changes in the blood. Further, the results suggest that an increase in omega-3 PUFAs decreases symptom severity and improves cognition in the CHR state through modulating effects of complement and coagulation proteins.</jats:p>
  • Access State: Open Access