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Media type:
E-Article
Title:
NeuroExaminer: an all-glass microfluidic device for whole-brain in vivo imaging in zebrafish
Contributor:
Mattern, Kai;
von Trotha, Jakob William;
Erfle, Peer;
Köster, Reinhard Wolfgang;
Dietzel, Andreas
Published:
Springer Science and Business Media LLC, 2020
Published in:
Communications Biology, 3 (2020) 1
Language:
English
DOI:
10.1038/s42003-020-1029-7
ISSN:
2399-3642
Origination:
Footnote:
Description:
AbstractWhile microfluidics enables chemical stimuli application with high spatio-temporal precision, light-sheet microscopy allows rapid imaging of entire zebrafish brains with cellular resolution. Both techniques, however, have not been combined to monitor whole-brain neural activity yet. Unlike conventional microfluidics, we report here an all-glass device (NeuroExaminer) that is compatible with whole-brain in vivo imaging using light-sheet microscopy and can thus provide insights into brain function in health and disease.