Description:
<jats:title>Abstract</jats:title><jats:p>We aimed to determine the indecisive association between tumor necrosis factor-related apoptosis-inducing ligand receptor 1 (<jats:italic>TRAIL-R1</jats:italic>) Thr209Arg polymorphism and inherited susceptibility to cancer. A meta-analysis combining data on 9,517 individuals was performed to assess the association between <jats:italic>TRAIL-R1</jats:italic> Thr209Arg and cancer incidence. The summary ORs with 95% CI calculated with the fixed effects model suggested that Thr209Arg was not significantly associated with cancer susceptibility (homozygous model: OR 0.98, 95% CI 0.88–1.09; heterozygous model: OR 0.95, 95% CI 0.87–1.04; allele frequency model: OR 0.99, 95% CI 0.94–1.05; dominant model: OR 0.98, 95% CI 0.91–1.05; recessive model: OR 1.01, 95% CI 0.92–1.10). Stratified analysis by ethnicity and cancer type yielded similar null associations. These statistical data suggest that Thr209Arg in exon 4 of the <jats:italic>TRAIL-R1</jats:italic> gene may not represent a modifier of susceptibility to cancer.</jats:p>