> Details

Charnaud, Sarah C.; McGready, Rose; Herten-Crabb, Asha; Powell, Rosanna; Guy, Andrew; Langer, Christine; Richards, Jack S.; Gilson, Paul R.; Chotivanich, Kesinee; Tsuboi, Takafumi; Narum, David L.; Pimanpanarak, Mupawjay; Simpson, Julie A.; Beeson, James G.; Nosten, François; Fowkes, Freya J. I.

Maternal-foetal transfer of Plasmodium falciparum and Plasmodium vivax antibodies in a low transmission setting

Reference
management

Bookmarks

Remove from
bookmarks

Share this on Whatsapp

Close

Bookmarks



You can manage bookmarks using lists, please log in to your user account for this.
  • Media type: E-Article
  • Title: Maternal-foetal transfer of Plasmodium falciparum and Plasmodium vivax antibodies in a low transmission setting
  • Contributor: Charnaud, Sarah C.; McGready, Rose; Herten-Crabb, Asha; Powell, Rosanna; Guy, Andrew; Langer, Christine; Richards, Jack S.; Gilson, Paul R.; Chotivanich, Kesinee; Tsuboi, Takafumi; Narum, David L.; Pimanpanarak, Mupawjay; Simpson, Julie A.; Beeson, James G.; Nosten, François; Fowkes, Freya J. I.
  • Published: Springer Science and Business Media LLC, 2016
  • Published in: Scientific Reports, 6 (2016) 1
  • Language: English
  • DOI: 10.1038/srep20859
  • ISSN: 2045-2322
  • Keywords: Multidisciplinary
  • Origination:
  • Footnote:
  • Description: <jats:title>Abstract</jats:title><jats:p>During pregnancy immunolglobulin G (IgG) antibodies are transferred from mother to neonate across the placenta. Studies in high transmission areas have shown transfer of <jats:italic>P. falciparum</jats:italic>-specific IgG, but the extent and factors influencing maternal-foetal transfer in low transmission areas co-endemic for both <jats:italic>P. falciparum</jats:italic> and <jats:italic>P. vivax</jats:italic> are unknown. Pregnant women were screened weekly for <jats:italic>Plasmodium</jats:italic> infection. Mother-neonate paired serum samples at delivery were tested for IgG to antigens from <jats:italic>P. falciparum</jats:italic>, <jats:italic>P. vivax</jats:italic> and other infectious diseases. Antibodies to malarial and non-malarial antigens were highly correlated between maternal and neonatal samples (median [range] spearman ρ = 0.78 [0.57–0.93]), although <jats:italic>Plasmodium</jats:italic> spp. antibodies tended to be lower in neonates than mothers. Estimated gestational age at last <jats:italic>P. falciparum</jats:italic> infection, but not <jats:italic>P. vivax</jats:italic> infection, was positively associated with antibody levels in the neonate (<jats:italic>P. falciparum</jats:italic> merozoite, spearman ρ median [range] 0.42 [0.33–0.66], <jats:italic>Pf</jats:italic>VAR2CSA 0.69; <jats:italic>P. vivax</jats:italic> ρ = 0.19 [0.09–0.3]). Maternal-foetal transfer of anti-malarial IgG to <jats:italic>Plasmodium</jats:italic> spp. antigens occurs in low transmission settings. <jats:italic>P. vivax</jats:italic> IgG acquisition is not associated with recent exposure unlike <jats:italic>P. falciparum</jats:italic> IgG, suggesting a difference in acquisition of antibodies. IgG transfer is greatest in the final weeks of pregnancy which has implications for the timing of future malaria vaccination strategies in pregnant women.</jats:p>
  • Access State: Open Access