• Media type: E-Article
  • Title: Identification of dabigatran etexilate major degradation pathways by liquid chromatography coupled to multi stage high-resolution mass spectrometry
  • Contributor: Amrani, Fatma; Secrétan, Philippe-Henri; Sadou-Yayé, Hassane; Aymes-Chodur, Caroline; Bernard, Mélisande; Solgadi, Audrey; Yagoubi, Najet; Do, Bernard
  • imprint: Royal Society of Chemistry (RSC), 2015
  • Published in: RSC Advances
  • Language: English
  • DOI: 10.1039/c5ra04251h
  • ISSN: 2046-2069
  • Origination:
  • Footnote:
  • Description: <p>The major degradation mechanisms of dabigatran etexilate were deduced in the context of stress testing. Under hydrolytic stress conditions, <italic>O</italic>-dealkylation may occur along with formation of benzimidic acid derivatives.</p>