• Media type: E-Article
  • Title: Density functional theory and liquid chromatography-multistage mass spectrometry to characterize raltitrexed photo-degradation mechanisms
  • Contributor: Sadou-Yayé, Hassane; Karoui, Maher; Secrétan, Philippe-Henri; Ghermani, Noureddine; Gillet, Jean-Michel; Safta, Fathi; Yagoubi, Najet; Do, Bernard
  • imprint: Royal Society of Chemistry (RSC), 2016
  • Published in: RSC Advances
  • Language: English
  • DOI: 10.1039/c6ra13144a
  • ISSN: 2046-2069
  • Origination:
  • Footnote:
  • Description: <p>The structure of raltitrexed photoproducts was elucidated by LC-ESI-HR-MS<sup>n</sup>. Photodegradation pathways are proposed, using DFT approach to support assumptions. Ralitrexed photodegrades as per photosensitization mechanisms.</p>