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Media type:
E-Article
Title:
The virulence factor LecB varies in clinical isolates: consequences for ligand binding and drug discovery
Contributor:
Sommer, Roman;
Wagner, Stefanie;
Varrot, Annabelle;
Nycholat, Corwin M.;
Khaledi, Ariane;
Häussler, Susanne;
Paulson, James C.;
Imberty, Anne;
Titz, Alexander
imprint:
Royal Society of Chemistry (RSC), 2016
Published in:Chemical Science
Language:
English
DOI:
10.1039/c6sc00696e
ISSN:
2041-6520;
2041-6539
Origination:
Footnote:
Description:
<p>The sequence of the virulence factor LecB differs significantly between the evolutionarily diverged PAO1- or PA14-like strains and can serve as marker for strain classification. Despite these variations, its comparable ligand selectivity makes LecB a highly promising target for anti-virulence therapy.</p>