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Media type:
E-Article
Title:
Diastereoselective reduction of the tricarbonyl moiety in bicyclic tetramates giving pyroglutamates
Contributor:
Josa-Culleré, Laia;
Christensen, Kirsten E.;
Moloney, Mark G.
imprint:
Royal Society of Chemistry (RSC), 2018
Published in:
Organic & Biomolecular Chemistry, 16 (2018) 15, Seite 2705-2710
Language:
English
DOI:
10.1039/c8ob00187a
ISSN:
1477-0520;
1477-0539
Origination:
Footnote:
Description:
<p>The formation of densely functionalised bicyclic tetramic acids by both stereoselective reduction and Grignard displacement of a Weinreb amide gives bioactive small molecules, with antibacterial activity along with some cancer-cell line inhibitory activity.</p>