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Media type:
E-Article
Title:
Two is better than one: difunctional high-affinity PSMA probes based on a [CpM(CO)3] (M = Re/99mTc) scaffold
Contributor:
Frei, Angelo;
Fischer, Eliane;
Childs, Bradley Covington;
Holland, Jason P.;
Alberto, Roger
imprint:
Royal Society of Chemistry (RSC), 2019
Published in:Dalton Transactions
Language:
English
DOI:
10.1039/c9dt02506e
ISSN:
1477-9226;
1477-9234
Origination:
Footnote:
Description:
<p>Multifunctional cyclopentadiene ligands are used to prepare difunctional and monofunctional, PSMA-targeting Re(<sc>i</sc>) and <sup>99m</sup>Tc(<sc>i</sc>) complexes. The difunctional rhenium complex is shown to bind the PSMA with an order of magnitude lower <italic>K</italic><sub>D</sub>.</p>