• Media type: E-Article
  • Title: Inhibition of osimertinib-resistant epidermal growth factor receptor EGFR-T790M/C797S
  • Contributor: Lategahn, Jonas; Keul, Marina; Klövekorn, Philip; Tumbrink, Hannah L.; Niggenaber, Janina; Müller, Matthias P.; Hodson, Luke; Flaßhoff, Maren; Hardick, Julia; Grabe, Tobias; Engel, Julian; Schultz-Fademrecht, Carsten; Baumann, Matthias; Ketzer, Julia; Mühlenberg, Thomas; Hiller, Wolf; Günther, Georgia; Unger, Anke; Müller, Heiko; Heimsoeth, Alena; Golz, Christopher; Blank-Landeshammer, Bernhard; Kollipara, Laxmikanth; Zahedi, René P.; [...]
  • Published: Royal Society of Chemistry (RSC), 2019
  • Published in: Chemical Science, 10 (2019) 46, Seite 10789-10801
  • Language: English
  • DOI: 10.1039/c9sc03445e
  • ISSN: 2041-6520; 2041-6539
  • Origination:
  • Footnote:
  • Description: We present inhibitors of drug resistant mutants of EGFR including T790M and C797S. In addition, we present the first X-ray crystal structures of covalent inhibitors in complex with C797S-mutated EGFR to gain insight into their binding mode.
  • Access State: Open Access