Diamante, Aurora;
Chaturbedy, Piyush K.;
Rowling, Pamela J. E.;
Kumita, Janet R.;
Eapen, Rohan S.;
McLaughlin, Stephen H.;
Roche, Marc de la;
Perez-Riba, Albert;
Itzhaki, Laura S.
Engineering mono- and multi-valent inhibitors on a modular scaffold
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Media type:
E-Article
Title:
Engineering mono- and multi-valent inhibitors on a modular scaffold
Contributor:
Diamante, Aurora;
Chaturbedy, Piyush K.;
Rowling, Pamela J. E.;
Kumita, Janet R.;
Eapen, Rohan S.;
McLaughlin, Stephen H.;
Roche, Marc de la;
Perez-Riba, Albert;
Itzhaki, Laura S.
imprint:
Royal Society of Chemistry (RSC), 2021
Published in:Chemical Science
Language:
English
DOI:
10.1039/d0sc03175e
ISSN:
2041-6520;
2041-6539
Origination:
Footnote:
Description:
<p>We exploit the simple modular architecture of repeat proteins to create a platform for single- and multi-functional display in diverse programmable geometries and demonstrate proof of concept by building potent inhibitors of a key signalling pathway.</p>