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Fiorentino, Francesco; Rotili, Dante; Mai, Antonello; Bolla, Jani R.; Robinson, Carol V.

Mass spectrometry enables the discovery of inhibitors of an LPS transport assembly via disruption of protein–protein interactions

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  • Media type: E-Article
  • Title: Mass spectrometry enables the discovery of inhibitors of an LPS transport assembly via disruption of protein–protein interactions
  • Contributor: Fiorentino, Francesco; Rotili, Dante; Mai, Antonello; Bolla, Jani R.; Robinson, Carol V.
  • Published: Royal Society of Chemistry (RSC), 2021
  • Published in: Chemical Communications, 57 (2021) 82, Seite 10747-10750
  • Language: English
  • DOI: 10.1039/d1cc04186j
  • ISSN: 1359-7345; 1364-548X
  • Origination:
  • Footnote:
  • Description: We employed a native MS-based method to quantify the dimerisation equilibrium of the LPS transport protein LptH. We then assessed the activity of the LPS transport inhibitor IMB-881 and identified new quinoline derivatives as LptH dimer disruptors.