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Media type:
E-Article
Title:
Revisiting a challenging p53 binding site: a diversity-optimized HEFLib reveals diverse binding modes in T-p53C-Y220C
Contributor:
Stahlecker, Jason;
Klett, Theresa;
Schwer, Martin;
Jaag, Simon;
Dammann, Marcel;
Ernst, Larissa N.;
Braun, Michael B.;
Zimmermann, Markus O.;
Kramer, Markus;
Lämmerhofer, Michael;
Stehle, Thilo;
Coles, Murray;
Boeckler, Frank M.
Published:
Royal Society of Chemistry (RSC), 2022
Published in:
RSC Medicinal Chemistry, 13 (2022) 12, Seite 1575-1586
Language:
English
DOI:
10.1039/d2md00246a
ISSN:
2632-8682
Origination:
Footnote:
Description:
Fragment screening of the challenging drug target T-p53-Y220C with our diversity optimized HEFLib leads to diverse reversible and covalent binding modes.