Published in:
Chemical Communications, 58 (2022) 63, Seite 8858-8861
Language:
English
DOI:
10.1039/d2cc02094g
ISSN:
1359-7345;
1364-548X
Origination:
Footnote:
Description:
<jats:p>A novel class of USP7 PROTACs were designed and synthesized. CST967, a CRBN-based degrader, showed potent and selective depletion of USP7 leading to apoptosis in multiple cancer lines.</jats:p>