Published in:
RSC Advances, 12 (2022) 52, Seite 33510-33515
Language:
English
DOI:
10.1039/d2ra05630e
ISSN:
2046-2069
Origination:
Footnote:
Description:
Substitution I253Q on a glycosylated IgG1 antibody allows microbial transglutaminase-mediated conjugation of a fluorophore or a clickable auristatin. The resulting antibody–drug conjugate showed excellent cell toxicity and no FcRn-mediated recycling.