• Media type: E-Article
  • Title: Blastocoel Fluid Biopsy
  • Contributor: Gianaroli, Luca; Albanese, Cristina; Tabanelli, Carla; Crippa, Andor; Magli, Maria Cristina
  • imprint: World Scientific Pub Co Pte Lt, 2019
  • Published in: Fertility & Reproduction
  • Language: English
  • DOI: 10.1142/s2661318219300034
  • ISSN: 2661-3182; 2661-3174
  • Keywords: General Earth and Planetary Sciences ; General Environmental Science
  • Origination:
  • Footnote:
  • Description: <jats:p> The identification of viable embryos for transfer is one of the main challenges in reproductive medicine. As chromosomal abnormalities are the major cause of implantation failure, preimplantation genetic testing of aneuploidy plays an important role in embryo selection. To make this approach more efficient, the possibility to retrieve informative DNA through a moderately invasive technique compared to the traditional forms of biopsy is appealing. Blastocoelic fluid is a valuable source of DNA. Its presence, as detected by whole genomic amplification, and the following analysis by comprehensive chromosome screening could add important information on the blastocyst ploidy condition and developmental potential. </jats:p>
  • Access State: Open Access