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Media type:
E-Article
Title:
Mechanism and Regulation of Cytoplasmic Dynein
Contributor:
Cianfrocco, Michael A.;
DeSantis, Morgan E.;
Leschziner, Andres E.;
Reck-Peterson, Samara L.
imprint:
Annual Reviews, 2015
Published in:Annual Review of Cell and Developmental Biology
Language:
English
DOI:
10.1146/annurev-cellbio-100814-125438
ISSN:
1530-8995;
1081-0706
Origination:
Footnote:
Description:
<jats:p>Until recently, dynein was the least understood of the cytoskeletal motors. However, a wealth of new structural, mechanistic, and cell biological data is shedding light on how this complicated minus-end-directed, microtubule-based motor works. Cytoplasmic dynein-1 performs a wide array of functions in most eukaryotes, both in interphase, in which it transports organelles, proteins, mRNAs, and viruses, and in mitosis and meiosis. Mutations in dynein or its regulators are linked to neurodevelopmental and neurodegenerative diseases. Here, we begin by providing a synthesis of recent data to describe the current model of dynein's mechanochemical cycle. Next, we discuss regulators of dynein, with particular focus on those that directly interact with the motor to modulate its recruitment to microtubules, initiate cargo transport, or activate minus-end-directed motility.</jats:p>