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Media type:
E-Article
Title:
BMP Signaling in Development, Stem Cells, and Diseases of the Gastrointestinal Tract
Contributor:
Zhang, Yongchun;
Que, Jianwen
Published:
Annual Reviews, 2020
Published in:
Annual Review of Physiology, 82 (2020) 1, Seite 251-273
Language:
English
DOI:
10.1146/annurev-physiol-021119-034500
ISSN:
0066-4278;
1545-1585
Origination:
Footnote:
Description:
The bone morphogenetic protein (BMP) pathway is essential for the morphogenesis of multiple organs in the digestive system. Abnormal BMP signaling has also been associated with disease initiation and progression in the gastrointestinal (GI) tract and associated organs. Recent studies using animal models, tissue organoids, and human pluripotent stem cells have significantly expanded our understanding of the roles played by BMPs in the development and homeostasis of GI organs. It is clear that BMP signaling regulates GI function and disease progression that involve stem/progenitor cells and inflammation in a tissue-specific manner. In this review we discuss these new findings with a focus on the esophagus, stomach, and intestine.