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Media type:
E-Article
Title:
Overexpression of dimethylarginine dimethylaminohydrolase 1 protects from angiotensin II-induced cardiac hypertrophy and vascular remodeling
Contributor:
Kopaliani, Irakli;
Jarzebska, Natalia;
Billoff, Silke;
Kolouschek, Anne;
Martens-Lobenhoffer, Jens;
Bornstein, Stefan R.;
Bode-Böger, Stefanie M.;
Ragavan, Vinitha N.;
Weiss, Norbert;
Mangoni, Arduino A.;
Deussen, Andreas;
Rodionov, Roman N.
Published:
American Physiological Society, 2021
Published in:
American Journal of Physiology-Heart and Circulatory Physiology, 321 (2021) 5, Seite H825-H838
Language:
English
DOI:
10.1152/ajpheart.00064.2021
ISSN:
0363-6135;
1522-1539
Origination:
Footnote:
Description:
We showed that overexpression of dimethylarginine dimethylaminohydrolase 1 (DDAH1) protects from angiotensin II-induced cardiovascular damage, progression of hypertension, and adverse vascular remodeling in vivo. This protective effect strongly depends on the dose and duration of angiotensin II infusion and is associated with decreased levels of asymmetric dimethylarginine (ADMA), preservation of endothelial function, inhibition of cardiovascular inflammation, as well as lower activity of matrix metalloproteinase-2 (MMP2). Our findings are highly clinically relevant, because they suggest that upregulation of DDAH1 might be a promising therapeutic approach against angiotensin II-induced end organ damage.