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Media type:
E-Article
Title:
Effects of in utero exposure to Δ-9-tetrahydrocannabinol on cardiac extracellular matrix expression and vascular transcriptome in rhesus macaques
Contributor:
Le, Hillary H.;
Shorey-Kendrick, Lyndsey E.;
Hinds, Monica T.;
McCarty, Owen J. T.;
Lo, Jamie O.;
Anderson, Deirdre E. J.
Published:
American Physiological Society, 2024
Published in:
American Journal of Physiology-Heart and Circulatory Physiology, 327 (2024) 3, Seite H701-H714
Language:
English
DOI:
10.1152/ajpheart.00181.2024
ISSN:
0363-6135;
1522-1539
Origination:
Footnote:
Description:
Prenatal cannabis use is increasing and despite the public health relevance, there is limited safety data regarding its impact on offspring cardiovascular health outcomes. We used a translational, nonhuman primate model of daily edible Δ-9-tetrahydrocannabinol (THC) consumption during pregnancy to assess its effects on the fetal cardiovascular system. THC-exposed fetal vascular tissues displayed upregulation of genes involved in cellular metabolism and inflammation, suggesting that prenatal THC exposure may impact fetal vascular tissues.