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Zheng, Tenghao; Camargo Tavares, Leticia; D’Amato, Mauro; Marques, Francine Z.

Constipation is associated with an increased risk of major adverse cardiac events in a UK population

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  • Media type: E-Article
  • Title: Constipation is associated with an increased risk of major adverse cardiac events in a UK population
  • Contributor: Zheng, Tenghao; Camargo Tavares, Leticia; D’Amato, Mauro; Marques, Francine Z.
  • Published: American Physiological Society, 2024
  • Published in: American Journal of Physiology-Heart and Circulatory Physiology, 327 (2024) 4, Seite H956-H964
  • Language: English
  • DOI: 10.1152/ajpheart.00519.2024
  • ISSN: 1522-1539; 0363-6135
  • Origination:
  • Footnote:
  • Description: Analyzing 408,354 participants of the UK Biobank, we show that constipation cases exhibited a significantly higher risk of major adverse cardiac events (MACEs) than those with regular bowel habits. In comparison with patients with constipation-free hypertension, patients with hypertension with constipation showed significantly higher odds of MACE and a 34% increased risk of subsequent MACE occurrence. Finally, we detected positive genetic correlations between constipation and MACE. This association holds potential for therapeutic exploitation and prevention based on individuals’ risk assessment.