Published in:American Journal of Physiology-Heart and Circulatory Physiology
Language:
English
DOI:
10.1152/ajpheart.00692.2021
ISSN:
1522-1539;
0363-6135
Origination:
Footnote:
Description:
<jats:p> To our knowledge, this study is the first to demonstrate that increased GLS1 expression and subsequent activation of glutaminolysis are associated with exacerbation of cardiac hypertrophy and fibrosis. Inhibiting GLS1 antagonized the adverse cardiac remodeling in vitro and in vivo, partly due to reduction of glutamine-derived metabolites, which are necessary for cellular growth and proliferation. Increased glutamine utilization for anabolic reactions in cardiac cells may be related to the pathogenesis and development of HF. </jats:p>