Oppelaar, Jetta J.;
Bouwmeester, Thomas A.;
Silova, Anastasia A.;
Collard, Didier;
Wouda, Rosa D.;
van Duin, Robert E.;
Rorije, Nienke M. G.;
Olde Engberink, Rik H. G.;
Danser, A. H. Jan;
van den Born, Bert-Jan H.;
Vogt, Liffert
Salt-sensitive trait of normotensive individuals is associated with altered autonomous cardiac regulation: a randomized controlled intervention study
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Media type:
E-Article
Title:
Salt-sensitive trait of normotensive individuals is associated with altered autonomous cardiac regulation: a randomized controlled intervention study
Contributor:
Oppelaar, Jetta J.;
Bouwmeester, Thomas A.;
Silova, Anastasia A.;
Collard, Didier;
Wouda, Rosa D.;
van Duin, Robert E.;
Rorije, Nienke M. G.;
Olde Engberink, Rik H. G.;
Danser, A. H. Jan;
van den Born, Bert-Jan H.;
Vogt, Liffert
Published:
American Physiological Society, 2023
Published in:
American Journal of Physiology-Renal Physiology, 325 (2023) 6, Seite F707-F716
Description:
Extracellular fluid expansion in normotensive individuals after salt loading is present in both salt-sensitive and salt-resistant individuals and is not discriminatory to the blood pressure response to sodium loading in a steady-state measurement. In normotensive subjects, the ability to sufficiently vasodilate seems to play a pivotal role in salt sensitivity. In a normotensive cohort, differences in sympathovagal balance are also present in low-salt conditions rather than being affected by salt loading. Whereas treatment and prevention of salt-sensitive blood pressure increase are mostly focused on renal sodium handling and extracellular volume regulation, our study suggests that an inability to adequately vasodilate and altered autonomous cardiac functioning are additional key players in the pathophysiology of salt-sensitive blood pressure increase.