Kessel, Friederike;
Steglich, Anne;
Hickmann, Linda;
Lira Martinez, Ricardo;
Gerlach, Michael;
Sequeira-Lopez, Maria Luisa S.;
Gomez, R. Ariel;
Hugo, Christian P. M.;
Todorov, Vladimir T.
Patterns of differentiation of renin lineage cells during nephrogenesis
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Media type:
E-Article
Title:
Patterns of differentiation of renin lineage cells during nephrogenesis
Contributor:
Kessel, Friederike;
Steglich, Anne;
Hickmann, Linda;
Lira Martinez, Ricardo;
Gerlach, Michael;
Sequeira-Lopez, Maria Luisa S.;
Gomez, R. Ariel;
Hugo, Christian P. M.;
Todorov, Vladimir T.
imprint:
American Physiological Society, 2021
Published in:American Journal of Physiology-Renal Physiology
Description:
<jats:p> The unifying feature of the renal renin lineage cells (RLCs) is their origin from renin-expressing progenitors. RLCs evolve to an embryologically heterogeneous large population in structures with different ancestry. RLCs are also targets for the widely used renin-angiotensin-system blockers, which modulate their phenotype. Unveiling the different differentiation patterns of RLCs in the developing kidney contributes to understanding changes in their cell fate in response to homeostatic challenges and the use of antihypertensive drugs. </jats:p>