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Taylor, Kylie M.; Au, Amy Y. M.; Herath, Sanjeeva; Succar, Lena; Wong, Jasmine; Erlich, Jonathan H.; Endre, Zoltán H.

Kidney functional reserve and damage biomarkers in subclinical chronic kidney disease and acute kidney injury

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  • Media type: E-Article
  • Title: Kidney functional reserve and damage biomarkers in subclinical chronic kidney disease and acute kidney injury
  • Contributor: Taylor, Kylie M.; Au, Amy Y. M.; Herath, Sanjeeva; Succar, Lena; Wong, Jasmine; Erlich, Jonathan H.; Endre, Zoltán H.
  • imprint: American Physiological Society, 2023
  • Published in: American Journal of Physiology-Renal Physiology
  • Language: English
  • DOI: 10.1152/ajprenal.00133.2023
  • ISSN: 1931-857X; 1522-1466
  • Keywords: Physiology
  • Origination:
  • Footnote:
  • Description: <jats:p> Early kidney function loss is poorly identified by serum creatinine (sCr)-based measurements. Direct kidney functional reserve (KFR) measurement before kidney injury and elevated urinary biomarkers clusterin and kidney injury molecule-1 detect subclinical chronic kidney disease (sCKD) after kidney injury despite normal range sCr and creatinine clearance. Reliance on sCr masks underlying sCKD. Acute kidney injury risk evaluation requires direct glomerular filtration rate measurement and KFR, whereas kidney damage biomarkers facilitate identification of prior subclinical injury. </jats:p>