Rodriguez-Niño, Angelica;
Pastene, Diego O.;
Hettler, Steffen A.;
Qiu, Jiedong;
Albrecht, Thomas;
Vajpayee, Srishti;
Perciaccante, Rossana;
Gretz, Norbert;
Bakker, Stephan J. L.;
Krämer, Bernhard K.;
Yard, Benito A.;
van den Born, Jacob
Influence of carnosine and carnosinase-1 on diabetes-induced afferent arteriole vasodilation: implications for glomerular hemodynamics
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Media type:
E-Article
Title:
Influence of carnosine and carnosinase-1 on diabetes-induced afferent arteriole vasodilation: implications for glomerular hemodynamics
Contributor:
Rodriguez-Niño, Angelica;
Pastene, Diego O.;
Hettler, Steffen A.;
Qiu, Jiedong;
Albrecht, Thomas;
Vajpayee, Srishti;
Perciaccante, Rossana;
Gretz, Norbert;
Bakker, Stephan J. L.;
Krämer, Bernhard K.;
Yard, Benito A.;
van den Born, Jacob
Published:
American Physiological Society, 2022
Published in:
American Journal of Physiology-Renal Physiology, 323 (2022) 1, Seite F69-F80
Language:
English
DOI:
10.1152/ajprenal.00232.2021
ISSN:
1522-1466;
1931-857X
Origination:
Footnote:
Description:
Dysregulation in glomerular hemodynamics favors hyperfiltration in diabetic kidney disease (DKD). Although carnosine supplementation ameliorates features of DKD, its effect on glomerular vasoregulation is not known. We assessed the influence of carnosine and carnosinase-1 (CN1) on afferent glomerular arteriole vasodilation and its association with glomerular size, hypertrophy, and nephrin expression in diabetic BTBR ob/ob mice. Our results provide evidence that carnosine feeding and CN1 overexpression likely affect intraglomerular pressure through vasoregulation of the afferent arteriole.