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Media type:
E-Article
Title:
Tidal exhaled nitric oxide in healthy, unsedated newborn infants with prenatal tobacco exposure
Contributor:
Hall, Graham L.;
Reinmann, Benjamin;
Wildhaber, Johannes H.;
Frey, Urs
Published:
American Physiological Society, 2002
Published in:
Journal of Applied Physiology, 92 (2002) 1, Seite 59-66
Language:
English
DOI:
10.1152/jappl.2002.92.1.59
ISSN:
8750-7587;
1522-1601
Origination:
Footnote:
Description:
Tidal fractional exhaled nitric oxide (Fe NO) changes were investigated in healthy, unsedated infants with or without prenatal tobacco exposure. Tidal flow (V˙), Fe NO, and CO2were measured in 20 healthy, unsedated infants [age: 25–58 days, length: 56.5 ± 2.5 (SE) cm]. NO output (V˙no) was calculated (V˙no = Fe NO × V˙). Two approaches were used to investigate within-breath changes of Fe NOand V˙no. First, we identified phases II and III from the expiratory capnogram. Second, we divided expiration into time-based quartiles. Tidal Fe NO (range: 14.5 ± 1.6 to 17.6 ± 2.1 parts/billion: quartile 4 and phase II, respectively) was not different between portions and exhibited significant negative V˙ dependence. V˙no was significantly dependent on the expiratory portion, with quartile 4 being significantly lower than the remaining expiratory portions. Infants exposed to prenatal cigarette smoke ( n = 7) exhibited significantly lower Fe NO and V˙no compared with nonexposed ( n = 13) infants. We conclude that tidal Fe NO is V˙ dependent and thatV˙no may be a more suitable outcome parameter in variable V˙ conditions. Prenatal tobacco exposure resulted in a decreased Fe NO and V˙no in infants.