> Details

Yarrow, Joshua F.; Wnek, Russell D.; Conover, Christine F.; Reynolds, Michael C.; Buckley, Kinley H.; Kura, Jayachandra R.; Sutor, Tommy W.; Otzel, Dana M.; Mattingly, Alex J.; Croft, Summer; Aguirre, J. Ignacio; Borst, Stephen E.; Beck, Darren T.; McCullough, Danielle J.

Bone loss after severe spinal cord injury coincides with reduced bone formation and precedes bone blood flow deficits

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  • Media type: E-Article
  • Title: Bone loss after severe spinal cord injury coincides with reduced bone formation and precedes bone blood flow deficits
  • Contributor: Yarrow, Joshua F.; Wnek, Russell D.; Conover, Christine F.; Reynolds, Michael C.; Buckley, Kinley H.; Kura, Jayachandra R.; Sutor, Tommy W.; Otzel, Dana M.; Mattingly, Alex J.; Croft, Summer; Aguirre, J. Ignacio; Borst, Stephen E.; Beck, Darren T.; McCullough, Danielle J.
  • imprint: American Physiological Society, 2021
  • Published in: Journal of Applied Physiology
  • Language: English
  • DOI: 10.1152/japplphysiol.00444.2021
  • ISSN: 8750-7587; 1522-1601
  • Keywords: Physiology (medical) ; Physiology
  • Origination:
  • Footnote:
  • Description: <jats:p> We provide the first direct evidence indicating femur and tibia blood flow (BF) deficits exist in conscious (awake) rats after severe contusion spinal cord injury (SCI), with the distal femur displaying the largest BF deficits. Reduced bone perfusion temporally coincided with unopposed bone resorption, as indicated by ongoing osteoclast-mediated bone resorption and a near absence of surface-level bone formation indices, which resulted in severe cancellous and cortical microstructural deterioration after SCI. </jats:p>
  • Access State: Open Access