> Details

Kim, Youngdoe; Lee, Young; Lee, Sungyoung; Kim, Nam Hee; Lim, Jeongmin; Kim, Young Jin; Oh, Ji Hee; Min, Haesook; Lee, Meehee; Seo, Hyeon-Jeong; Lee, So-Hyun; Sung, Joohon; Cho, Nam H.; Kim, Bong-Jo; Han, Bok-Ghee; Elston, Robert C.; Won, Sungho; Lee, Juyoung

On the Estimation of Heritability with Family-Based and Population-Based Samples

Reference
management

Bookmarks

Remove from
bookmarks

Share this on Whatsapp

Close

Bookmarks



You can manage bookmarks using lists, please log in to your user account for this.
  • Media type: E-Article
  • Title: On the Estimation of Heritability with Family-Based and Population-Based Samples
  • Contributor: Kim, Youngdoe; Lee, Young; Lee, Sungyoung; Kim, Nam Hee; Lim, Jeongmin; Kim, Young Jin; Oh, Ji Hee; Min, Haesook; Lee, Meehee; Seo, Hyeon-Jeong; Lee, So-Hyun; Sung, Joohon; Cho, Nam H.; Kim, Bong-Jo; Han, Bok-Ghee; Elston, Robert C.; Won, Sungho; Lee, Juyoung
  • Published: Hindawi Limited, 2015
  • Published in: BioMed Research International, 2015 (2015), Seite 1-9
  • Language: English
  • DOI: 10.1155/2015/671349
  • ISSN: 2314-6133; 2314-6141
  • Keywords: General Immunology and Microbiology ; General Biochemistry, Genetics and Molecular Biology ; General Medicine
  • Origination:
  • Footnote:
  • Description: <jats:p>For a family-based sample, the phenotypic variance-covariance matrix can be parameterized to include the variance of a polygenic effect that has then been estimated using a variance component analysis. However, with the advent of large-scale genomic data, the genetic relationship matrix (GRM) can be estimated and can be utilized to parameterize the variance of a polygenic effect for population-based samples. Therefore narrow sense heritability, which is both population and trait specific, can be estimated with both population- and family-based samples. In this study we estimate heritability from both family-based and population-based samples, collected in Korea, and the heritability estimates from the pooled samples were, for height, 0.60; body mass index (BMI), 0.32; log-transformed triglycerides (log TG), 0.24; total cholesterol (TCHL), 0.30; high-density lipoprotein (HDL), 0.38; low-density lipoprotein (LDL), 0.29; systolic blood pressure (SBP), 0.23; and diastolic blood pressure (DBP), 0.24. Furthermore, we found differences in how heritability is estimated—in particular the amount of variance attributable to common environment in twins can be substantial—which indicates heritability estimates should be interpreted with caution.</jats:p>
  • Access State: Open Access