Published in:
BioMed Research International, 2019 (2019), Seite 1-10
Language:
English
DOI:
10.1155/2019/1851740
ISSN:
2314-6133;
2314-6141
Origination:
Footnote:
Description:
The human opportunistic fungal pathogenCandida albicanscauses a severe health burden while the biofilms formed byC. albicanspresent a kind of infections that are hard to cure, highlighting the pressing need for new antifungal drugs againstC. albicans. This study was to explore the antifungal activities of lycorine hydrochloride (LH) againstC. albicans. The minimal inhibitory concentration (MIC) of LH againstC. albicansSC5314 was 64μM. Below its MIC, LH demonstrated antivirulence property by suppressing adhesion, filamentation, biofilm formation, and development, as well as the production of extracellular phospholipase and exopolymeric substances (EPS). The cytotoxicity of LH against mammalian cells was low, with half maximal inhibitory concentrations (IC50) above 256μM. Moreover, LH showed a synergistic effect with AmB, although its interaction with fluconazole, as well as caspofungin, was indifferent. Thus, our study reports the potential use of LH, alone or in combination with current antifungal drugs, to fightC. albicansinfections.