Rodriguez-Niño, Angelica;
Hauske, Sibylle J.;
Herold, Anna;
Qiu, Jiedong;
van den Born, Jacob;
Bakker, Stephan J. L.;
Krämer, Bernhard K.;
Yard, Benito A.
Serum Carnosinase-1 and Albuminuria Rather than theCNDP1Genotype Correlate with Urinary Carnosinase-1 in Diabetic and Nondiabetic Patients with Chronic Kidney Disease
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Media type:
E-Article
Title:
Serum Carnosinase-1 and Albuminuria Rather than theCNDP1Genotype Correlate with Urinary Carnosinase-1 in Diabetic and Nondiabetic Patients with Chronic Kidney Disease
Contributor:
Rodriguez-Niño, Angelica;
Hauske, Sibylle J.;
Herold, Anna;
Qiu, Jiedong;
van den Born, Jacob;
Bakker, Stephan J. L.;
Krämer, Bernhard K.;
Yard, Benito A.
Published:
Hindawi Limited, 2019
Published in:
Journal of Diabetes Research, 2019 (2019), Seite 1-12
Language:
English
DOI:
10.1155/2019/6850628
ISSN:
2314-6745;
2314-6753
Origination:
Footnote:
Description:
Background. Carnosinase-1 (CN-1) can be detected in 24 h urine of healthy individuals and patients with type 2 diabetes (T2DM). We aimed to assess whether urinary CN-1 is also reliably measured in spot urine and investigated its association with renal function and the albumin/creatinine ratio (ACR). We also assessed associations between theCNDP1(CTG)ngenotype and CN-1 concentrations in serum and urine.Methods. Patients with T2DM (n=85) and nondiabetic patients with chronic kidney disease (CKD) (n=26) stratified by albuminuria (ACR≤300 mg/gorACR>300 mg/g) recruited from the nephrology clinic and healthy subjects (n=24) were studied.Results. Urinary CN-1 was more frequently detected and displayed higher concentrations in patients withACR>300 mg/gas compared to those withACR≤300 mg/girrespective of the baseline disease (T2DM: 554 ng/ml [IQR 212-934 ng/ml] vs. 31 ng/ml [IQR 31-63 ng/ml] (p<0.0001) and nondiabetic CKD: 197 ng/ml [IQR 112-739] vs. 31 ng/ml [IQR 31-226 ng/ml] (p=0.015)). A positive correlation between urinary CN-1 and ACR was found (r=0.68,p<0.0001). Multivariate linear regression analysis revealed that ACR and serum CN-1 concentrations but not eGFR or the CNDP1 genotype are independent predictors of urinary CN-1, explaining 47% of variation of urinary CN-1 concentrations (R2=0.47,p<0.0001).Conclusion. These results confirm and extend previous findings on urinary CN-1 concentrations, suggesting that assessment of CN-1 in spot urine is as reliable as in 24 h urine and may indicate that urinary CN-1 in macroalbuminuric patients is primarily serum-derived and not locally produced.