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Media type:
E-Article
Title:
B7‐H3 and Its Role in Antitumor Immunity
Contributor:
Loos, Martin;
Hedderich, Dennis M.;
Friess, Helmut;
Kleeff, Jörg
Published:
Wiley, 2010
Published in:
Journal of Immunology Research, 2010 (2010) 1
Language:
English
DOI:
10.1155/2010/683875
ISSN:
2314-8861;
2314-7156
Origination:
Footnote:
Description:
B7‐H3 is one of the most recently identified members of the B7/CD28 superfamily of costimulatory molecules serving as an accessory modulator of T‐cell response. Recently, B7‐H3 expression has been reported in several human cancers indicating an additional function of B7‐H3 as a regulator of antitumor immunity. However, its precise physiologic role is still elusive, because both stimulatory and inhibitory capacities have been demonstrated. This paper summarizes the available data on B7‐H3 in the regulation of T‐cell response focusing on its potential role in antitumor immunity.