Description:
<jats:p>The ready accessibility of (<jats:italic>R</jats:italic>)-<jats:italic>α</jats:italic>-aminoadipic acid by enzymatic cleavage of cephalosporin C (CephC) in the production of 7-aminocephalosporanic acid (7-ACA) on a large scale makes it a favorable chiral pool building block for the synthesis of unusual amino acids. A route for the synthesis of C-5-alkenyl and C-6-alkylidene derivatives of (<jats:italic>R</jats:italic>)-pipecolic acid is described which utilizes (<jats:italic>R</jats:italic>)-<jats:italic>α</jats:italic>-aminoadipic acid as the enantiomerically pure starting material. Moreover, the synthesis of azido and triazolyl derivatives of (<jats:italic>R</jats:italic>)-<jats:italic>α</jats:italic>-aminoadipic acid is reported.</jats:p>