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Sakthivel, G.; Dey, Amitabha; Nongalleima, Kh.; Chavali, Murthy; Rimal Isaac, R. S.; Singh, N. Surjit; Deb, Lokesh

In VitroandIn VivoEvaluation of Polyherbal Formulation against Russell’s Viper and Cobra Venom and Screening of Bioactive Components by Docking Studies

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  • Media type: E-Article
  • Title: In VitroandIn VivoEvaluation of Polyherbal Formulation against Russell’s Viper and Cobra Venom and Screening of Bioactive Components by Docking Studies
  • Contributor: Sakthivel, G.; Dey, Amitabha; Nongalleima, Kh.; Chavali, Murthy; Rimal Isaac, R. S.; Singh, N. Surjit; Deb, Lokesh
  • imprint: Hindawi Limited, 2013
  • Published in: Evidence-Based Complementary and Alternative Medicine
  • Language: English
  • DOI: 10.1155/2013/781216
  • ISSN: 1741-427X; 1741-4288
  • Keywords: Complementary and alternative medicine
  • Origination:
  • Footnote:
  • Description: <jats:p>The present study emphasizes to reveal the antivenom activity of<jats:italic>Aristolochia bracteolata</jats:italic>Lam.,<jats:italic>Tylophora indica</jats:italic>(Burm.f.) Merrill, and<jats:italic>Leucas aspera S.</jats:italic>which were evaluated against venoms of<jats:italic>Daboia russelli russelli</jats:italic>(Russell’s viper) and<jats:italic>Naja naja</jats:italic>(Indian cobra). The aqueous extracts of leaves and roots of the above-mentioned plants and their polyherbal (1 : 1 : 1) formulation at a dose of 200 mg/kg showed protection against envenomed mice with LD<jats:sub>50</jats:sub>doses of 0.44 mg/kg and 0.28 mg/kg against Russell’s viper and cobra venom, respectively. In<jats:italic>in vitro</jats:italic>antioxidant activities sample extracts showed free radical scavenging effects in dose dependent manner. Computational drug design and docking studies were carried out to predict the neutralizing principles of type I phospholipase A<jats:sub>2</jats:sub>(PLA<jats:sub>2</jats:sub>) from Indian common krait venom. This confirmed that aristolochic acid and leucasin can neutralize type I PLA<jats:sub>2</jats:sub>enzyme. Results suggest that these plants could serve as a source of natural antioxidants and common antidote for snake bite. However, further studies are needed to identify the lead molecule responsible for antidote activity.</jats:p>
  • Access State: Open Access