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Media type:
E-Article
Title:
Matrix Metalloproteinases in Cerebral Vasospasm following Aneurysmal Subarachnoid Hemorrhage
Contributor:
Mehta, Vivek;
Russin, Jonathan;
Spirtos, Alexandra;
He, Shuhan;
Adamczyk, Peter;
Amar, Arun P.;
Mack, William J.
Published:
Hindawi Limited, 2013
Published in:
Neurology Research International, 2013 (2013), Seite 1-4
Language:
English
DOI:
10.1155/2013/943761
ISSN:
2090-1852;
2090-1860
Origination:
Footnote:
Description:
Delayed cerebral vasospasm is a significant cause of morbidity and mortality following aneurysmal subarachnoid hemorrhage (SAH). While the cellular mechanisms underlying vasospasm remain unclear, it is believed that inflammation may play a critical role in vasospasm. Matrix metalloproteinasees (MMPs) are a family of extracellular and membrane-bound proteases capable of degrading the blood-rain barrier (BBB). As such, MMP upregulation following SAH may result in a proinflammatory extravascular environment capable of inciting delayed cerebral vasospasm. This paper presents an overview of MMPs and describes existing data pertinent to delayed cerebral vasospasm.