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Media type:
E-Article
Title:
Thienothiopyransulfonamides as Complexing Agents for thePreparation of Dual Carbonic Anhydrase Inhibitors
Contributor:
Supuran, Claudiu T.
Published:
Wiley, 1995
Published in:
Metal-Based Drugs, 2 (1995) 6, Seite 327-330
Language:
English
DOI:
10.1155/mbd.1995.327
ISSN:
0793-0291;
1687-5486
Origination:
Footnote:
Description:
Co(II); Zn(II) and Cu(II) complexes of two new sulfonamide carbonic anhydrase (CA) inhibitors,derivatives of thienothiopyran‐2‐sulfonamide, were prepared and characterized by analytic, spectroscopic,magnetic and conductimetric measurements. The new complexes are more potent CA inhibitors than theparent sulfonamides, with IC50 values around 0.1 nM, against isozyme CA II.