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Ressler, Sigrun; Scheiden, René; Dreier, Kerstin; Laich, Andreas; Müller-Holzner, Elisabeth; Pircher, Haymo; Morandell, Dieter; Stein, Ines; Viertler, Hans-Peter; Santer, Frédéric R.; Widschwendter, Andreas; Even, Jos; Jansen-Dürr, Pidder; Capesius, Catherine; Zwerschke, Werner

High-risk Human Papillomavirus E7 Oncoprotein Detection in Cervical Squamous Cell Carcinoma

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  • Media type: E-Article
  • Title: High-risk Human Papillomavirus E7 Oncoprotein Detection in Cervical Squamous Cell Carcinoma
  • Contributor: Ressler, Sigrun; Scheiden, René; Dreier, Kerstin; Laich, Andreas; Müller-Holzner, Elisabeth; Pircher, Haymo; Morandell, Dieter; Stein, Ines; Viertler, Hans-Peter; Santer, Frédéric R.; Widschwendter, Andreas; Even, Jos; Jansen-Dürr, Pidder; Capesius, Catherine; Zwerschke, Werner
  • imprint: American Association for Cancer Research (AACR), 2007
  • Published in: Clinical Cancer Research
  • Language: English
  • DOI: 10.1158/1078-0432.ccr-07-1222
  • ISSN: 1557-3265; 1078-0432
  • Keywords: Cancer Research ; Oncology
  • Origination:
  • Footnote:
  • Description: <jats:title>Abstract</jats:title> <jats:p>Purpose: Persistent infections by high-risk human papillomavirus (HPV) types are the main etiologic factor for cervical cancer. The objective of this study was to evaluate whether high-risk E7 oncoprotein is adequate as a marker for the detection of cervical cancer.</jats:p> <jats:p>Experimental Design: HPV typing was done in biopsies from 58 cervical carcinoma and 22 normal cervical squamous epithelia. The HPV-16 E7, HPV-18 E7, and HPV-45 E7 oncoprotein levels were monitored by immunohistochemistry and compared with those of p16INK4a and Ki67.</jats:p> <jats:p>Results: Fifty-five (94.8%) tumors were high-risk HPV-DNA–positive (46 HPV-16, 2 HPV-16 and HPV-18, 4 HPV-18, 1 HPV-33, and 2 HPV-45). HPV-DNA could not be detected in three tumors (5.2%). High HPV E7 oncoprotein levels were shown in 57 cervical cancers (98.3%), without correlation between expression levels and tumor stages.</jats:p> <jats:p>Conclusion: This is the first study which systematically analyzes the levels of the major HPV oncoproteins in cervical carcinomas demonstrating that the high-risk HPV E7 proteins are regularly expressed in these cancers. This suggests that high-risk E7 oncoproteins are necessary for cervical cancers and apparently essential as tumor marker.</jats:p>
  • Access State: Open Access